Brian J Day Selected Research

AEOL 10150

1/2018	Neuroprotective Effects of AEOL10150 in a Rat Organophosphate Model.
7/2017	Oxidative Stress Contributes to Status Epilepticus Associated Mortality.
12/2016	From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity.
7/2014	Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects.
3/2011	AEOL10150: a novel therapeutic for rescue treatment after toxic gas lung injury.
5/2010	Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.
11/2009	Extracellular superoxide dismutase regulates cardiac function and fibrosis.
2/2007	Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury.
10/2002	Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia.

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Brian J Day Research Topics

Disease

20	Inflammation (Inflammations) 01/2021 - 05/2008
9	Mitochondrial Diseases (Mitochondrial Disease) 03/2012 - 01/2004
8	Lung Diseases (Lung Disease) 12/2021 - 04/2004
6	Infections 01/2022 - 04/2004
6	Respiratory Hypersensitivity 12/2021 - 10/2010
6	Lung Injury 05/2013 - 01/2003
5	Cystic Fibrosis (Mucoviscidosis) 01/2020 - 04/2004
5	Neuroinflammatory Diseases 01/2019 - 01/2017
5	Status Epilepticus (Complex Partial Status Epilepticus) 01/2019 - 10/2015
5	Ischemia 04/2015 - 10/2002
5	Neoplasms (Cancer) 04/2012 - 07/2006
4	Parkinson Disease (Parkinson's Disease) 01/2021 - 04/2007
4	Asthma (Bronchial Asthma) 10/2020 - 01/2003
4	Berylliosis 01/2018 - 10/2004
4	Chronic Obstructive Pulmonary Disease (COPD) 05/2013 - 06/2009
3	Wounds and Injuries (Trauma) 01/2019 - 07/2003
3	Epilepsy (Aura) 12/2017 - 03/2012
3	Hypoxia (Hypoxemia) 02/2007 - 01/2003
2	Parkinsonian Disorders (Parkinsonism) 01/2021 - 04/2007
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2018 - 10/2010
2	Temporal Lobe Epilepsy 12/2017 - 10/2015
2	Cardiotoxicity 04/2015 - 11/2009
2	Acute Lung Injury 07/2013 - 09/2003
2	Breast Neoplasms (Breast Cancer) 04/2012 - 02/2012
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2012 - 04/2007
2	Fibrosis (Cirrhosis) 11/2009 - 02/2008
2	Cardiomyopathies (Cardiomyopathy) 04/2007 - 05/2002
1	Human Influenza (Influenza) 01/2022
1	Virus Diseases (Viral Diseases) 01/2022
1	Airway Obstruction (Choking) 01/2020
1	Pneumonia (Pneumonitis) 01/2020
1	Sarcoidosis (Schaumann Disease) 01/2018
1	Tics (Tic) 01/2016
1	Cognitive Dysfunction 10/2015
1	Heart Diseases (Heart Disease) 04/2015
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 08/2014

Drug/Important Bio-Agent (IBA)

27	AntioxidantsIBA 01/2021 - 10/2002
15	Glutathione (Reduced Glutathione)IBA 01/2017 - 05/2002
11	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2017 - 10/2002
9	AEOL 10150IBA 01/2018 - 10/2002
8	CytokinesIBA 01/2022 - 01/2003
8	MetalloporphyrinsIBA 01/2021 - 10/2002
7	SmokeIBA 10/2015 - 03/2006
7	Proteins (Proteins, Gene)FDA Link 04/2012 - 04/2004
5	Oxidants (Oxidizing Agents)IBA 01/2019 - 01/2003
5	BerylliumIBA 01/2018 - 10/2004
4	2-chloroethyl ethyl sulfideIBA 07/2014 - 03/2009
3	Thioredoxin-Disulfide ReductaseIBA 01/2020 - 01/2012
3	Superoxide DismutaseIBA 03/2012 - 03/2003
3	FlavonoidsIBA 01/2012 - 07/2006
3	Mitochondrial DNA (mtDNA)IBA 04/2007 - 01/2004
3	Superoxides (Superoxide)IBA 03/2003 - 12/2002
2	Particulate MatterIBA 12/2021 - 10/2020
2	Peroxidase (Myeloperoxidase)IBA 01/2020 - 02/2009
2	Nerve AgentsIBA 01/2019 - 07/2017
2	Mesalamine (Mesalazine)FDA LinkGeneric 01/2018 - 10/2010
2	Pilocarpine (Ocusert)FDA LinkGeneric 12/2017 - 07/2017
2	Glutamate-Cysteine LigaseIBA 01/2017 - 02/2012
2	Biomarkers (Surrogate Marker)IBA 12/2016 - 10/2010
2	Chemical Warfare AgentsIBA 01/2016 - 07/2014
2	ChlorineIBA 04/2015 - 10/2010
2	Pharmaceutical PreparationsIBA 04/2015 - 04/2012
2	Mustard Gas (Sulfur Mustard)IBA 07/2014 - 05/2010
2	NADPH Oxidases (NAD(P)H oxidase)IBA 07/2013 - 03/2003
2	1,3-dimethylthioureaIBA 07/2013 - 10/2010
2	AEOL 11207IBA 03/2012 - 04/2007
2	chrysinIBA 01/2012 - 07/2006
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2012 - 11/2009
2	DNA (Deoxyribonucleic Acid)IBA 11/2010 - 03/2009
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2010 - 03/2003
2	PorphyrinsIBA 04/2007 - 02/2007
2	Therapeutic UsesIBA 04/2007 - 01/2003
2	ManganeseIBA 04/2007 - 02/2007
2	Oxygen (Dioxygen)IBA 02/2007 - 01/2003
2	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 11/2006 - 04/2004
1	Interleukin-8 (Interleukin 8)IBA 01/2022
1	Antiviral Agents (Antivirals)IBA 01/2022
1	E-Cigarette VaporIBA 01/2022
1	Biological ProductsIBA 12/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Dopamine (Intropin)FDA LinkGeneric 01/2021
1	Interleukin-33IBA 10/2020
1	MucinsIBA 01/2020
1	Nicotine FDA Link 01/2020
1	Hypochlorous Acid (Hypochlorite)IBA 01/2020
1	SomanIBA 01/2019
1	AcetylcholinesteraseIBA 01/2019
1	Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric 01/2018
1	OrganophosphatesIBA 01/2018
1	Isoflurophate (DFP)FDA Link 01/2018
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018
1	TOR Serine-Threonine KinasesIBA 12/2017
1	Ribosomal Protein S6IBA 12/2017
1	Scopolamine (Hyoscine)FDA Link 07/2017
1	Diazepam (Valium)FDA LinkGeneric 07/2017
1	Dimercaprol (B.A.L.)FDA Link 01/2017
1	thiocyanateIBA 08/2015
1	Ranolazine FDA Link 04/2015
1	insulin B (9-23)IBA 08/2014

Therapy/Procedure

13	Therapeutics 01/2021 - 01/2003